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Agebio Explained

Onegevity Science Team

How does Agebio work?

Agebio calculates an estimation of Biological Age from a set of clinical blood measures that are used extensively in the health-care system. Physicians rely on blood biomarkers to assess an individual's risks for developing diabetes, heart disease, liver disease, immune deficiencies, and more. The blood biomarkers chosen for Agebio were picked because they represent the most impactful set of measures highly used by the medical community to assess a person's general health.

Physicians trust these measures because they are relatively consistent across populations and labs, have well-understood meanings regarding the systems they reflect and provide crucial insight for guiding the treatment of their patients. Clinical lab measures are robust, interpretable, and directly reflect your current health, and they are conveniently available from a single blood draw. For these reasons, blood biomarkers are reliable for Agebio to use to interpret Biological Age and provide actionable advice that is relevant to your health.

For a given individual, Agebio can address questions such as: Is my body aging faster than my chronological age? Is my metabolic age accelerated relative to my immune age? How does my rate of aging compare to other adults? Your results then guide the recommendations made to optimize your wellness, minimize your Biological Age, and reduce your risk for common chronic disease conditions as reflected in the clinically validated measures. Personalized actionability is at the heart of Agebio.  

Agebio is not intended to diagnose, treat, or prevent any disease.  Always consult with your health-care practitioner about concerns regarding a medical condition.

Other Biological Age Estimators 

Several other excellent predictors of Biological Age exist, such as telomere length and DNA methylation.   While these can be useful, they are not without their challenges. Telomere length indeed tends to decrease as human age, but this does not necessarily imply that actively increasing telomere length would increase lifespan.1 Telomere length is likely a mechanism of replicative aging that limits the number of times a cell replicates, which is quite advantageous if you are interested in preventing the spread of cancer. This is an important trade-off that humans evolved to make: trading senescence (the process of deterioration with age) for reduced cancer risk. Additionally, it is unclear how one would increase telomere length in vivo. Any treatments along these lines would likely require drugs, stem-cell transplants, or gene therapies that are at this point both expensive and unproven.

Additionally, while cellular senescence is widely viewed as a key process in aging, it does not address other key "hallmarks of aging" such as genomic instability, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, stem cell exhaustion, and altered intercellular communication.2

DNA methylation (DNAm) is another predictor of Biological Age that has raised considerable interest.3 DNAm focuses on a different hallmark than telomeres, epigenetic alterations. "Epigenetic clocks" have excellent predictive power, on par with Agebio, and thus are a good measure of biological age.   However, they, unfortunately, tell little about how an individual can optimize their own wellness and do not allow for actionable recommendations the way a test based on validated and interpretable clinical labs does.

One small study has shown that combined administration of Growth Hormone, Metformin, and DHEA can reverse an individual's 'epigenetic clock,` but whether that reversal is overall beneficial to an individual's wellness is very controversial.4 There are significant safety concerns about widely administering anti-aging hormonal therapies.5  

It is through the study of multi-omic measures and full biological systems that Agebio has come about. Its convenient, repeatable, reliable, actionable, and personalized—and is being used worldwide to help individuals understand how fast their internal clock is ticking.

How is Agebio calculated?

Agebio is calculated using the Klemera-Doubal (KD) algorithm, which is a theoretically optimal method of calculating Biological Age using linear biomarkers of aging.6 It is not only theoretically optimal but has been shown to be more effective at predicting all-cause mortality than chronological age, as well as reflecting in physical capability, cognitive decline, self-reported health, and physical appearance in midlife.7-8

Biological age, from blood biomarkers using the KD algorithm, has been shown to be effective at quantifying of wellness, with chronic disease conditions generally reflected in higher biological ages relative to chronological age, and most importantly was modifiable through the application of healthy lifestyle changes. Agebio is based on this algorithm over other methods for several reasons:

Opaque machine learning techniques, such as Deep Nets, may provide a more accurate prediction of Chronological Age, but their opaqueness prevents personalized actionability.

Additionally, we found in using interpretable regression-based techniques (Lasso, Elastic-net, Robust Regression), that bias was introduced. It resulted in the young generally appearing older than they are and the old generally appearing younger than they were. When attempting to quantify wellness relative to aging, consistently identifying the young as less well and the elderly as more well is not a desirable property.

The KD algorithm provides consistently unbiased results across the human lifespan.

Agebio: Transforming the Way We Age

The Agebio scores are derived from the observations of thousands of men and women. Just as men and women have different expected lifespans and different health concerns, Agebio uses different models for the prediction of biological age for each sex. The Agebio Biological Age Score combines factors of metabolic, immunologic, hematologic, hormonal, and organ health into a single score that represents a holistic picture of your wellness. Additionally, age scores are calculated for five key systems: Hematological-Immune, Metabolic, Lipid, Kidney, and Liver. This allows individuals to focus on improving systems that are most relevant to their health. Each system contains actionable possibilities that will, in turn, alter one's Biological Age Score.

Discover how your lifestyle has been affecting you, and transform the way you age with knowledge from Agebio.

1 Simons, Mirre JP. "Questioning causal involvement of telomeres in aging." Ageing research reviews 24 (2015): 191-196.

2 López-Otín, Carlos, et al. "The hallmarks of aging." Cell 153.6 (2013): 1194-1217.

3. Horvath, Steve. "DNA methylation age of human tissues and cell types." Genome biology 14.10 (2013): 3156.

4. Fahy, Gregory M., et al. "Reversal of epigenetic aging and immunosenescent trends in humans." Aging cell 18.6 (2019): e13028.

5. Anderson, Lindsey J., Jamie M. Tamayose, and Jose M. Garcia. "Use of growth hormone, IGF-I, and insulin for anabolic purpose: pharmacological basis, methods of detection, and adverse effects." Molecular and cellular endocrinology 464 (2018): 65-74.

6. Klemera, Petr, and Stanislav Doubal. "A new approach to the concept and computation of biological age." Mechanisms of ageing and development 127.3 (2006): 240-248.

7. Levine, Morgan E. "Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?." Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences 68.6 (2013): 667-674.

8. Belsky, Daniel W., et al. "Quantification of biological aging in young adults." Proceedings of the National Academy of Sciences 112.30 (2015): E4104-E4110.

9. Earls, John C., et al. "Multi-omic biological age estimation and its correlation with wellness and disease phenotypes: a longitudinal study of 3,558 individuals." The Journals of Gerontology: Series A 74.Supplement_1 (2019): S52-S60.